Protein Details: Voltage-gated sodium channel subunit beta-1

Protein ID

ICDB_Pro_0771

Protein Name

Voltage-gated sodium channel subunit beta-1

Gene Name

SCN1B

Organism

Homo sapiens (Human)

Length

218 amino acids

AlphaFoldDB

AF-Q07699-F1-model_v4.pdb

Function

Regulatory subunit of multiple voltage-gated sodium channel complexes that play important roles in excitable membranes in brain; heart and skeletal muscle. Enhances the presence of the pore-forming alpha subunit at the cell surface and modulates channel gating characteristics and the rate of channel inactivation. Modulates the activity of multiple pore-forming alpha subunits; such as SCN1A; SCN2A; SCN3A; SCN4A; SCN5A and SCN10A.; [Isoform 2]: Cell adhesion molecule that plays a critical role in neuronal migration and pathfinding during brain development. Stimulates neurite outgrowth . Has no regulatory function on the SCN2A sodium channel complex .

Sequence

MGRLLALVVGAALVSSACGGCVEVDSETEAVYGMTFKILCISCKRRSETNAETFTEWTFRQKGTEEFVKILRYENEVLQLEEDERFEGRVVWNGSRGTKDLQDLSIFITNVTYNHSGDYECHVYRLLFFENYEHNTSVVKKIHIEVVDKANRDMASIVSEIMMYVLIVVLTIWLVAEMIYCYKKIAAATETAAQENASEYLAITSESKENCTGVQVAE

PDB Structures

6AGF 6J8G 6J8H 6J8I 6J8J 7W77 7W7F 7W9K 7W9L 7W9M 7W9P 7W9T 7XM9 7XMF 7XMG 7XVE 7XVF 8FHD 8G1A 8GZ1 8GZ2 8I5B 8I5G 8I5X 8I5Y 8J4F 8S9B 8S9C

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Atrial Fibrillation;Familial;13 and Developmental And Epileptic Encephalopathy 52

Location

Central Neurons; Peripheral Neurons; skeletal muscle; heart; glia

DOI ID

10.1038/nature02399

RefSeq

NP_001028.1 [Q07699-1]; NP_001308534.1; NP_950238.1 [Q07699-2]